1. How to Use the Medical Literature and this Book to Improve Your Patient     Care
2. The Philosophy Of Evidence-Based Medicine
3. What Is the Question?
4. Finding the Evidence
5. Why Study Results Mislead: Bias and Random Error

Part B. Therapy
6. Therapy (Randomized Trials)
7. Does Treatment Lower Risk? Understanding the Results
8. Confidence Intervals
9. Advanced Topics in the Validity of Therapy Trials
9.1 An Illustration of Bias And Random Error
9.2 Surprising Results of Randomized Trials
9.3 Randomized Trials Stopped Early for Benefit
9.4 The Principle of Intention-To-Treat
9.5 N Of 1 Randomized Controlled Trials
9.6 Clinical Decision Support Systems
10. Advanced Topics in the Results of Therapy Trials
10.1 Hypothesis Testing
10.2 Understanding the Results: More About Odds Ratios
10.3 What Determines the Width of the Confidence Interval?
10.4 Composite Endpoints
10.5 Measuring Patients' Experience
11. Advanced Topics in Applying the Results of Therapy Trials
11.1 Applying Results to Individual Patients
11.2 Example Numbers Needed to Treat
11.3 Dealing With Misleading Presentations of Clinical Trial Results
11.4 Surrogate Outcomes
11.5 Qualitative Research

Part C. Harm
12. Harm
13. Harm (Observational Studies)
13.1 Advanced Topics in Harm: Correlation And Regression

Part D. Diagnosis
14. The Process of Diagnosis
15. Differential Diagnosis
16. Diagnostic Tests
17. Advanced Topics in Diagnosis
17.1 Spectrum Bias
17.2 Examples of Likelihood Ratios
17.3 Measuring Agreement Beyond Chance
17.4 Clinical Prediction Rules

Part E. Prognosis
18. Prognosis

Part F. Summarizing the Evidence
19. Summarizing the Evidence
20. Advanced Topics in Systematic Reviews
20.1 Reporting Bias
20.2 Fixed-Effects and Random-Effects Models
20.3 Making Sense of Variability in Study Results
20.4 When to Believe a Subgroup Analysis

Part G. Moving From Evidence to Action

21. How to Use a Patient Management Recommendation
22. Advanced Topics in Moving from Evidence to Action
22.1. Economic Analysis
22.2. Decision Making and the Patient
22.3. Moving From Evidence to Action: Recommendations About Screening
22.4. Grading Recommendations
22.5. Drug Class Effects
22.6. Parallel but Separate Goals: Evidence-Based Practitioners and
          Evidence-Based Care
22.7. Changing Behavior to Apply Best Evidence in Practice
22.8. Teachers' Guides to the Users' Guides