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coronary heart disease
Users' Guides to the Medical Literature
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results
1.
Part B Therapy >
Chapter 11.4. Surrogate Outcomes
> Are the Results Valid? > Is There a Strong, Independent, Consistent Association Between the Surrogate Outcome and the Patient-important Outcome? >
For example, ecologic studies such as the Seven Countries Study
16
suggested a strong...
2.
Part B Therapy >
Chapter 11.4. Surrogate Outcomes
> Are the Results Valid? > Have Randomized Trials of the Same Drug Class Shown That Improvement in the Surrogate Endpoint Has Consistently Led to Improvement in the Target Outcome? >
For example, several large trials of primary and secondary prevention of coronary heart disease...
3.
Part B Therapy >
Chapter 9.2. Surprising Results of Randomized Trials
> When Randomized Controlled Trial Results Have Contradicted Observational Studies of Patient-Important Endpoints >
Table 9.2-3 Refuted Evidence From Observational Studies
a
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