randomized controlled trials
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GLOSSARY
N-of-1 randomized controlled trial
An experiment designed to determine the effect of an intervention or exposure on a single study participant. In one N-of-1 design, the patient...
Continue readingAn experiment designed to determine the effect of an intervention or exposure on a single study participant. In one N-of-1 design, the patient undergoes pairs of treatment periods organized so that 1 period involves the use of the experimental treatment and 1 period involves the use of an alternate treatment or placebo. The patient and clinician are blinded, if possible, and outcomes are monitored. Treatment periods are replicated until the clinician and patient are convinced that the treatments are definitely different or definitely not different.