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Care at the Close of Life (CCL)
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Terms are derived from
Users' Guides to the Medical Literature: A Manual for Evidence-Based Practice, 2nd Edition
The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Care at the Close of Life: Evidence and Experience.
Updated May 2013.
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A surgical opening into the stomach, usually created to enable liquid artificial nutrition via a percutaneous tube, frequently referred to as tube feedings. See
General Health Questionnaire (GHQ)
Developed as a screening tool to detect those likely to have or be at risk of developing psychiatric disorders, the GHQ asks whether the respondent has experienced a particular symptom or behavior recently. It assesses domains of depression, anxiety, somatic symptoms, and social withdrawal. Available in 12-, 28-, 30- or 60-item versions.
The degree to which the results of a study can be generalized to settings or samples other than the ones studied.
Generalized anxiety disorder
A disorder in which an individual experiences excessive, uncontrollable, and irrational worry that is disproportionate to the actual source of worry.
Generic health-related quality of life
Generic health-related quality of life (HRQL) measures contain items covering all relevant areas of HRQL. They are designed for administration to people with any kind of underlying health problem (or no problem at all). Generic HRQL measures allow comparisons across diseases or conditions. See also
Health-related quality of life
A situation in which a particular phenotype may result from more than one genetic variant.
A specific genetic variant known to be associated with a recognizable trait.
The entire collection of genetic information (or genes) that an organism possesses.
Genome-wide association (GWA) study
A study that evaluates association of genetic variation with outcomes or traits of interest by using 100 000 to 1 000 000 or more markers across the genome.
The genetic constitution of an individual, either overall or at a specific gene.
Geometry of a network
A graphical representation of the distribution of treatments and their comparisons across the network.
Gastroesophageal reflux disease. GERD is caused by the reflux of stomach contents into the esophagus.
Granulocyte-macrophage colony-stimulating factor, available as the recombinant drug sargramostim, used to stimulate the bone marrow to produce white blood cells in cases of severe neutropenia.
A method having established or widely accepted accuracy for determining a diagnosis that provides a standard to which a new screening or diagnostic test can be compared. The method need not be a single or simple procedure but could include follow-up of patients to observe the evolution of their conditions or the consensus of an expert panel of clinicians.
Softening of the cervix on bimanual examination. May be detected by 8 weeks' gestational age. The progressive edema that develops during pregnancy softens the consistency of the cervix tip to approximate that of the lips (Goodell sign).
Grief, complicated or prolonged
Morbid grief reactions (eg, ruminations about the deceased, hostility) that are deviations from “normal” grief and require aggressive intervention.
Normal bereavement reactions that, though painful, move the survivor toward a reconciliation with the loss and an ability to carry on with his/her life.
A reflexive spasm of the abdominal musculature in the setting of peritoneal irritation, such as with appendicitis, which cannot be overcome by distraction (also referred to as rigidity).
Contraction of the abdominal musculature, often due to fear of pain rather than actual pain, but which can usually be partially or fully overcome by using relaxation and distraction techniques.
Guiding Responsive Action for Corrections in End-of-life (GRACE) Project
An initiative of the Robert Wood Johnson Foundation Promoting Excellence in End-of-Life Care program administered by Volunteers of America to promote hospice care in prisons for inmates with terminal illnesses.
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