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The Rational Clinical Examination
David L. Simel, Drummond Rennie
Myocardial Infarction
David L. Simel, Stephen W. Goodacre, L. Kristin Newby
Clinical Scenario


Topics Discussed: chest pain, myocardial infarction

Excerpt: "A 62-year-old woman experienced chest discomfort while walking from the parking garage to your hospital. She decided to stop in the emergency department for evaluation. The discomfort has been present for about 10 to 12 minutes and is creating a dull ache in her left shoulder and arm. As you interview her, she is diaphoretic and experiencing the chest discomfort. Her blood pressure is 145/95 mm Hg. The lungs are clear to auscultation, whereas the cardiac examination reveals an S4 systolic sound but no murmur. The pulses are equal in all of her extremities. An electrocardiogram (ECG) result seems normal, but your hospital provides neither computerized ECG reports nor computerized estimates of the probability of a myocardial infarction (MI). She experiences relief after a sublingual nitroglycerin tablet. You find that she was recently diagnosed with diabetes and systolic hypertension, and she has been trying to stop smoking. There was no nausea with the discomfort, although she observes frequent epigastric discomfort that responds to antacids. She takes cimetidine, which helps with her discomfort. ..."
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