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The Rational Clinical Examination
David L. Simel, Drummond Rennie
Myasthenia Gravis
Katalin Scherer, Richard Bedlack
Reference Standard Tests

Topics Discussed: acetylcholine receptor antibody, eyelid ptosis, likelihood ratio, make the diagnosis, myasthenia gravis, prior probability

Excerpt: "Myasthenia gravis is a rare disease. The prevalence in the United States is reported at approximately 14.1 in 100 000.1-3 Men older than 50 years have the highest incidence, with the peak at approximately aged 70 years. Women have 2 incidence peaks: one at approximately aged 20 to 40 years and one at approximately aged 70 years.4,5 The prior probability of myasthenia gravis in the general population among patients presenting with symptoms is unknown. Because of the high prevalence of the disease in the included studies (close to 50%), the results may not be generalizable to the general population...."
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