Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part E Prognosis
Chapter e18.1. How to Use an Article About Genetic Association
John Attia, John P. A. Ioannidis, Ammarin Thakkinstian, Mark McEvoy, Rodney J. Scott, Cosetta Minelli, John Thompson, Claire Infante-Rivard, Gordon Guyatt
Sections:
Clinical Scenario, Finding the Evidence, Background Concepts, Are the Results of the Study Valid?, What are the Results of the Study?, How Can I Apply the Results to Patient Care?, Clinical Resolution, References, Compiled Clinical Scenarios
Topics Discussed:
genetic predisposition to disease
Excerpt:
"A 55-year-old man consults you, worried about his risk of developing
Alzheimer disease. His grandfather had dementia in his 70s, and
his own father was diagnosed with dementia at 65 years. He has been
a smoker since he was 20 years of age, works as an electrician,
and has been taking antihypertensive medication (thiazide and 
-blocker)
for the last 5 years. He has never had his cholesterol level checked.
He has recently read a news story about genetic tests and asks you
whether he should have any genetic test for dementia risk, in particular
for a gene called APOE...."
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