Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part G Moving from Evidence to Action
Chapter 22.5. Drug Class Effects
Regina Kunz, Heiner C. Bucher, Finlay A. McAlister, Anne Holbrook, Gordon Guyatt
A second head-to-head-comparison (PROVE-IT study) that compared high-dose atorvastatin (80 mg/d)...
drug class effects, grading recommendations
"The IPD meta-analysis included 14 large RCTs,
and in addition, you have decided to focus on 2 head-to-head comparison
trials. Looking back to Table 22.5-2, we
see that because the evidence comes from RCTs,
it holds promise to provide high-quality evidence. Still, we need
to look carefully at 5 possible limitations...."
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