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Guyatt G, Rennie D, Meade MO, Cook DJ
Part B Therapy
Chapter 9.2. Surprising Results of Randomized Trials
Christina Lacchetti, John Ioannidis, Gordon Guyatt
Table 9.2-2 Refuted Evidence From Studies of Physiologic or Surrogate Endpoints


Topics Discussed: beta-blocker, breast cancer, cardiac arrest, colorectal cancer, emphysema, pulmonary, epinephrine, heart failure, chronic, interpretation of results, lung volume reduction, misleading results, morphine, randomized controlled trials, respiratory distress syndrome, adult, surprising results, surrogate outcomes

Excerpt: "Table 9.2-2 shows examples in which RCTs of patient-important outcomes refuted results of studies using physiologic or surrogate endpoints. Surrogate endpoint studies were either observational or randomized. Whereas in most cases the surrogate studies were overly optimistic, in some, surrogates did not suggest any benefit (or even suggested harm), but patient-important outcomes demonstrated benefit...."
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