Institutional Subscriptions   Individual Subscriptions 
Editors/Authors   Librarians   Newsletter   Site Tour   A-Z Index   About   Contact Us   Help 
Log In | Log In via Athens
Disable Autosuggest
Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part B Therapy
Chapter 9.2. Surprising Results of Randomized Trials
Christina Lacchetti, John Ioannidis, Gordon Guyatt
Table 9.2-2 Refuted Evidence From Studies of Physiologic or Surrogate Endpoints

Topics Discussed: beta-blocker, breast cancer, cardiac arrest, colorectal cancer, emphysema, pulmonary, epinephrine, heart failure, chronic, interpretation of results, lung volume reduction, misleading results, morphine, randomized controlled trials, respiratory distress syndrome, adult, surprising results, surrogate outcomes

Excerpt: "Table 9.2-2 shows examples in which RCTs of patient-important outcomes refuted results of studies using physiologic or surrogate endpoints. Surrogate endpoint studies were either observational or randomized. Whereas in most cases the surrogate studies were overly optimistic, in some, surrogates did not suggest any benefit (or even suggested harm), but patient-important outcomes demonstrated benefit...."
Log in to read the full chapter:
Subscriber Log In
Forgot your username/password?
Get full access to JAMAevidence two ways:
Subscribe to JAMAevidence
JAMAevidence is a subscription-
based website dedicated to the learning, teaching, and practicing of evidence-based medicine.
Pay Per View
Timed access to all of JAMAevidence
24 hours for $34.95
48 hours for $54.95
Copyright © American Medical Association. All rights reserved.  |  JAMA  |  McGraw-Hill Global Education Holdings, LLC.
Privacy Notice. Any use is subject to the Terms of Use and Notice. Additional Credits and Copyright Information.
Your IP address is