Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part B Therapy
Chapter 9.2. Surprising Results of Randomized Trials
Christina Lacchetti, John Ioannidis, Gordon Guyatt
Table 9.2-2 Refuted Evidence From Studies of Physiologic or Surrogate Endpoints
Topics Discussed:
beta-blocker, breast cancer, cardiac arrest, colorectal cancer, emphysema, pulmonary, epinephrine, heart failure, chronic, interpretation of results, lung volume reduction, misleading results, morphine, randomized controlled trials, respiratory distress syndrome, adult, surrogate outcomes
Excerpt:
"Table 9.2-2 shows examples in which RCTs of patient-important
outcomes refuted results of studies using physiologic or surrogate
endpoints. Surrogate endpoint studies were either observational or randomized. Whereas
in most cases the surrogate studies were overly optimistic, in some,
surrogates did not suggest any benefit (or even suggested harm),
but patient-important outcomes demonstrated benefit...."
Log in to read the full chapter:
Get full access to JAMAevidence two ways:
Subscribe to JAMAevidence
JAMAevidence is a subscription-
based website dedicated to the learning, teaching, and practicing of evidence-based medicine.
Pay Per View
Timed access to all of JAMAevidence
24 hours for $29.95
48 hours for $49.95