Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part B Therapy
Chapter 9.2. Surprising Results of Randomized Trials
Christina Lacchetti, John Ioannidis, Gordon Guyatt
When Randomized Controlled Trial Results Have Contradicted Nonhuman Studies
Topics Discussed:
herpes zoster disease, interpretation of results, misleading results, randomized controlled trials, spinal cord injuries
Excerpt:
"Table 9.2-1 provides examples in which
animal or tissue studies gave misleading inferences. In the typical
scenario, an attractive promise in nonhuman research is not validated
when tested in humans. It is uncommon to see negative results in
nonhuman experiments being followed by proof of effectiveness on
human studies, probably because interventions that do not
show promise at the basic science and animal experimentation level
are unlikely to move toward human experimentation...."
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