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Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part A The Foundations
Chapter 4. Finding the Evidence
Ann McKibbon, Peter Wyer, Roman Jaeschke, Dereck Hunt
Soundness of Evidence-Based Approach


Topics Discussed: approach to medical literature, finding the evidence, information resources, qualitative research, summarizing the evidence

Excerpt: "Efficient searching involves choosing information sources appropriate for the clinical question—in much the same way you choose diagnostic tests appropriate for your patient's symptoms. The scheme in Table 4-1 offers an initial guideline for making choices. If a fully integrated and reliable resource (a "system" type resource) is likely to address your question, you would be wise to consider it. Depending on the level of detail you need, a practice guideline or systematic review, or a well-done synopsis of a guideline or systematic review, could be the next best option. For some questions, you will seek individual studies.An evidence-based information resource will provide access to a representative sample of the highest quality of evidence addressing a clinical question. Evidence-based resources that summarize evidence will explicitly frame their question, conduct a comprehensive search, assess the validity of the individual studies, and if appropriate provide a pooled estimate of the impact of the outcomes of interest (see Chapter 19, Summarizing the Evidence). Evidence-based resources that provide recommendations will use existing systematic reviews, or conduct their own, to provide best estimates of benefit and risk of alternative management strategies for all patient-important outcomes. They then will use an appropriate system to grade recommendations and will make explicit underlying values and preferences (see Chapter 21, How to Use a Patient Management Recommendation)...."
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