Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part F Summarizing the Evidence
Chapter 20.4. When to Believe a Subgroup Analysis
Gordon Guyatt, Peter Wyer, John Ioannidis
Clinical Scenario
Topics Discussed:
advanced cardiac life support, cardiac arrest, effects of subgroup analysis, epinephrine, statistics in subgroup analyses, subgroup analysis, vasopressins
Excerpt:
"You are the medical director of the emergency medical service
in your region. The chair of your resuscitation training committee
observes that your protocols for cardiac arrest do not include vasopressin.
He points to a study in the New England Journal of Medicine that
suggested that vasopressin, relative to epinephrine, saved lives
in patients presenting in asystole1 and that its
use was supported by an editorial in the same issue.2 He
also mentions that the American Heart Association has released an
update of their well-known Advanced Cardiac Life Support guidelines3 and
observes that they list vasopressin as a valid alternative to epinephrine,
at the same time acknowledging that this recommendation is controversial.4..."
Log in to read the full chapter:
Get full access to JAMAevidence two ways:
Subscribe to JAMAevidence
JAMAevidence is a subscription-
based website dedicated to the learning, teaching, and practicing of evidence-based medicine.
Pay Per View
Timed access to all of JAMAevidence
24 hours for $29.95
48 hours for $49.95