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Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part F Summarizing the Evidence
Chapter 19. Summarizing the Evidence
Gordon Guyatt, Roman Jaeschke, Kameshwar Prasad, Deborah J. Cook
Did the Review Explicitly Address a Sensible Clinical Question?


Topics Discussed: asking clinical questions, asthma, clinical trial eligibility criteria, magnesium, review literature, status asthmaticus, summarizing the evidence, systematic reviews, validity of evidence

Excerpt: "Consider a systematic review that pooled results from all cancer therapeutic modalities for all types of cancer to generate a single estimate of the effect on mortality. Next, consider a review that pooled the results of the effects of all doses of all antiplatelet agents (including aspirin, sulfinpyrazone, dipyridamole, ticlodipine, and clopidogrel) on major thrombotic events (including myocardial infarctions, strokes, and acute arterial insufficiency in the leg) and mortality in patients with clinically manifest atherosclerosis (whether in the heart, head, or lower extremities). Finally, reflect on a review that addressed the influence of a wide range of aspirin doses to prevent thrombotic stroke in patients who had experienced a transient ischemic attack (TIA) in the carotid circulation...."
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