Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part C Harm
Chapter 12. Harm (Observational Studies)
Mitchell Levine, John Ioannidis, Ted Haines, Gordon Guyatt
Clinical Scenario
Topics Discussed:
adverse effects, observational studies, peanut hypersensitivity, soy milk
Excerpt:
"You are a general practitioner with a 29-year-old patient who
is 8 months pregnant with her second child. Her first child, who
is now 3 years old, had demonstrated an intolerance to cow's
milk as an infant. He was switched to soy formula, and then soy
milk, which he subsequently tolerated very well. At age 2 years,
cow's milk was reintroduced without any problems, and he
has been receiving cow's milk since. She was planning to
start feeding her next child soy formula at birth but heard from
a neighbor that it can increase the risk of peanut allergy in her
child, a potentially serious and lifelong disease. She asks for
your advice on the topic. Because you are not particularly familiar
with this issue, you inform your patient that you will examine the
evidence and discuss your findings with her when she returns for
her next prenatal visit in 1 week...."
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