Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part B Therapy
Chapter 11.3. Dealing With Misleading Presentations of Clinical Trial Results
Victor Montori, John Ioannidis, Roman Jaeschke, P. J. Devereaux, Holger Schünemann, Mohit Bhandari, Gordon Guyatt
Dealing With Misleading Presentations of Clinical Trial Results: Introduction
Topics Discussed:
bias, epidemiologic, clinical trials, interpretation of results, misleading results, research outcome, understanding the results
Excerpt:
"Science is often not objective.1 The choice
of research questions, the methods to collect and analyze data,
and the interpretation of results all reflect the Weltanschauung,
or worldview of the investigator.2 Investigators' emotional
investment in their own ideas, and their personal interest in academic
success and advancement, may further compromise scientific objectivity.
Investigators often overemphasize the importance of their findings
and the quality of their work and choose interpretations that will
enhance chances of success in obtaining funds from granting bodies.
Scrutiny of the work of the current authors will demonstrate we
are not immune to these lapses...."
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