Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part B Therapy
Chapter 10.4. Composite Endpoints
Gordon Guyatt, Victor Montori, Ignacio Ferreira-González, Jason W. Busse, Holger Schünemann, Roman Jaeschke, Gaietà Permanyer-Miralda
The LIFE trial9 investigators randomized 9193 patients older than 55 years, with...
aspirin, atherosclerosis, clopidogrel, composite endpoints, confidence interval, diabetic nephropathy, health outcomes, hypertension, relative risk reduction
"Comfort with using a CEP as the basis of clinical decision
making rests in part on confidence that similar RRRs apply
to the more and the less important components. Investigators should
therefore construct CEPs in which the biology would lead
us to expect similar effects across components...."
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