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Guyatt G, Rennie D, Meade MO, Cook DJ
Part B Therapy
Chapter 10.4. Composite Endpoints
Gordon Guyatt, Victor Montori, Ignacio Ferreira-González, Jason W. Busse, Holger Schünemann, Roman Jaeschke, GaietĂ  Permanyer-Miralda
The LIFE trial9 investigators randomized 9193 patients older than 55 years, with...


Topics Discussed: aspirin, atherosclerosis, clopidogrel, composite endpoints, confidence interval, diabetic nephropathy, health outcomes, hypertension, relative risk reduction

Excerpt: "Comfort with using a CEP as the basis of clinical decision making rests in part on confidence that similar RRRs apply to the more and the less important components. Investigators should therefore construct CEPs in which the biology would lead us to expect similar effects across components...."
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