Institutional Subscriptions   Individual Subscriptions 
Editors/Authors   Librarians   Newsletter   Site Tour   A-Z Index   About   Contact Us   Help 
Log In | Log In via Athens
Disable Autosuggest
Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part B Therapy
Chapter 10.4. Composite Endpoints
Gordon Guyatt, Victor Montori, Ignacio Ferreira-González, Jason W. Busse, Holger Schünemann, Roman Jaeschke, GaietĂ  Permanyer-Miralda
On the other hand, consider a trial of 4 doses of perioperative aspirin in patients undergoing...

Topics Discussed: aspirin, chronic obstructive airway disease, composite endpoints, glucocorticoids, health outcomes, incorporating patient values and preferences

Excerpt: "Consider a situation in which all components of a CEP are of equal importance to the patient. Were this true, making the assumption that the effect of the intervention on each component endpoint is similar in both relative and absolute terms will not be misleading. If patients consider death, stroke, and MI to be of equal importance, it does not much matter how a 5% ARR in the CEP is distributed across a CEP including these 3 components. Assuming similar effects across components will not adversely affect decision making, even if treatment effects differ substantially...."
Log in to read the full chapter:
Subscriber Log In
Forgot your username/password?
Get full access to JAMAevidence two ways:
Subscribe to JAMAevidence
JAMAevidence is a subscription-
based website dedicated to the learning, teaching, and practicing of evidence-based medicine.
Pay Per View
Timed access to all of JAMAevidence
24 hours for $34.95
48 hours for $54.95
Copyright © American Medical Association. All rights reserved.  |  JAMA  |  McGraw-Hill Global Education Holdings, LLC.
Privacy Notice. Any use is subject to the Terms of Use and Notice. Additional Credits and Copyright Information.
Your IP address is