Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part B Therapy
Chapter 10.4. Composite Endpoints
Gordon Guyatt, Victor Montori, Ignacio Ferreira-González, Jason W. Busse, Holger Schünemann, Roman Jaeschke, Gaietà Permanyer-Miralda
On the other hand, consider a trial of 4 doses of perioperative aspirin in patients undergoing...
Topics Discussed:
aspirin, chronic obstructive airway disease, composite endpoints, glucocorticoids, health outcomes, incorporating patient values and preferences
Excerpt:
"Consider a situation in which all components of
a CEP are of equal importance to the patient. Were this
true, making the assumption that the effect of the intervention on each
component endpoint is similar in both relative and absolute
terms will not be misleading. If patients consider death, stroke,
and MI to be of equal importance, it does not much matter how a
5% ARR in the CEP is distributed across
a CEP including these 3 components. Assuming similar effects
across components will not adversely affect decision making, even
if treatment effects differ substantially...."
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