Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part B Therapy
Chapter 10.4. Composite Endpoints
Gordon Guyatt, Victor Montori, Ignacio Ferreira-González, Jason W. Busse, Holger Schünemann, Roman Jaeschke, Gaietà Permanyer-Miralda
Clinical Scenario
Topics Discussed:
angina pectoris, angiogram, composite endpoints, coronary revascularization, health outcomes
Excerpt:
"You are an internist seeing a 76-year-old man who, despite taking carefully
titrated 
-blockers, nitrates, aspirin, an angiotensin-converting
enzyme inhibitor, and a statin, has angina that significantly restricts
his activities. Throughout the last year, his symptoms have
worsened and now significantly limit his quality of life. You suggest
to him the possibility of referral to a cardiologist for cardiac catheterization
and possible revascularization. The patient expresses reluctance
to undergo invasive management and wonders how much benefit he might
expect from an invasive approach...."
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