Users' Guides to the Medical Literature
Guyatt G, Rennie D, Meade MO, Cook DJ
Part B Therapy
Chapter 10.1. Hypothesis Testing
Gordon Guyatt, Kameshwar Prasad, Roman Jaeschke, Deborah J. Cook, Stephen Walter
Hypothesis Testing: Introduction
enalapril, hydralazine, hypothesis testing, null hypothesis testing
"For every treatment, there is a true, underlying effect that
any individual experiment can only estimate (see Chapter 5, Why Study Results Mislead: Bias and Random Error). Investigators use
statistical methods to advance their understanding of this true effect.
One approach to statistical exploration is to begin with what is called
a null hypothesis and try to disprove that
hypothesis. Typically, the null hypothesis suggests there is no
difference between treatments being compared...."
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