JAMAevidence

Fundamental tools for understanding and applying the medical literature and making clinical diagnoses.

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Core Topics in Evidence-Based Medicine

	Learn how to recognize, classify, and prioritize important patient or policy problems.
	Construct clinical questions that facilitate an efficient search for evidence.
	Gather important and convincing evidence from high-quality repositories of the health literature.
	Systematically check best available evidence for indications of validity, importance, and usefulness.
	Interpret the applicability of evidence to specific problems, given patient preferences and values.

	In Practice
	From The Rational Clinical Examination Deep Vein Thrombosis A 60-year-old man referred with suspected deep vein thrombosis (DVT) cut the plantar surface of... Continue reading See also: *Make the Diagnosis: Deep Vein Thrombosis*

	May 2013 \| Featured on JAMAevidence
	JAMAevidence PODCAST David L. Simel, MD, MHS, discusses the clinical examination for carotid bruits. (9:19) Download this Podcast \| View All New Chapter From The Rational Clinical Examination Liver Disease and Cirrhosis Updates to the Glossary May 2013: AST:ALT ratio (AAR); AST:platelet ratio index (APRI); Bonacini cirrhosis discriminant score (CDS); Facial telangiectasia; Lok index; Palmar erythema; Spider nevi Click to view the full JAMAevidence Glossary or only the Care at the Close of Life Glossary. Top searched terms in the glossary Bayesian analysis Fixed-effects models Heterogeneity Meta-regression analysis Random-effects model CALCULATOR Likelihood Ratio Nomogram

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	Custom Syllabus
	Custom Syllabus is an education tool that allows instructors and learners to create courses and topics based on the content of the JAMAevidence web site, as well as other materials. Find out more

	My JAMAevidence
	JAMAevidence subscribers have access to features such as saved images and tables, saved worksheets and question wizards, and bookmarking.

Users' Guides to the Medical Literature

Users' Guides to the Medical Literature
A Manual for Evidence-Based Clinical Practice, 2nd Edition

FEATURED
Composite Endpoints

You are an internist seeing a 76-year-old man who, despite taking carefully titrated β-blockers, nitrates... Continue reading

The Rational Clinical Examination

The Rational Clinical Examination
Evidence-Based Clinical Diagnosis

FEATURED
Sinusitis

Sinusitis may be thought of as "rhinosinusitis" to emphasis the role of nasal symptoms but requires... Continue reading

Care at the Close of Life

Care at the Close of Life
Evidence and Experience

FEATURED
Palliative Care for Patients with Amyotrophic Lateral Sclerosis: “Prepare for the Worst and Hope for the Best”

Dr SP is a 56-year-old neurologist specializing in the care of patients with amyotrophic lateral sclerosis (ALS)... Continue reading

	Education Guides
	Users' Guides to the Medical Literature Education Guide: Appraising Evidence About Therapy View Online Slideshow \| Download PowerPoint View all Education Guides View sample slideshow from Users’ Guides to the Medical Literature View sample slideshow from The Rational Clinical Examination View sample slideshow from Care at the Close of Life

	This Week's JAMA
	JAMA May 21, 2013 • This Week in JAMA • Advances in Regulatory Science at the Food and Drug Administration Advances in Regulatory Science at the FDA • Identification of Physician Impairment Identification of Physician Impairment • Medication Nonadherence A Diagnosable and Treatable Medical Condition Medication Nonadherence